Is Genetic Evolution Predictable?

被引：388

作者：

Stern, David L. ^{[1
]}

Orgogozo, Virginie ^{[2
]}

机构：

[1] Princeton Univ, Howard Hughes Med Inst, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA

[2] Univ Paris 06, CNRS, F-75005 Paris, France

来源：

SCIENCE | 2009年 / 323卷 / 5915期

关键词：

MORPHOLOGICAL EVOLUTION; DROSOPHILA-MELANOGASTER; FLOWERING TIME; BRISTLE NUMBER; ADAPTATION; DIFFERENCE; FRIGIDA; LOCUS; ARABIDOPSIS; POPULATION;

D O I：

10.1126/science.1158997

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ever since the integration of Mendelian genetics into evolutionary biology in the early 20th century, evolutionary geneticists have for the most part treated genes and mutations as generic entities. However, recent observations indicate that all genes are not equal in the eyes of evolution. Evolutionarily relevant mutations tend to accumulate in hotspot genes and at specific positions within genes. Genetic evolution is constrained by gene function, the structure of genetic networks, and population biology. The genetic basis of evolution may be predictable to some extent, and further understanding of this predictability requires incorporation of the specific functions and characteristics of genes into evolutionary theory.

引用

页码：746 / 751

页数：6

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