Tumor resistance to apoptosis

被引：476

作者：

Fulda, Simone ^{[1
]}

机构：

[1] Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 124卷 / 03期

关键词：

apoptosis; cancer; death receptor; mitochondria; IAPs; X-LINKED INHIBITOR; NF-KAPPA-B; FAS APO-1/CD95 GENE; DEATH RECEPTOR; IN-VITRO; DR5/TRAIL-RECEPTOR-2; GENE; HOMOZYGOUS DELETIONS; CANCER DEVELOPMENT; PROGNOSTIC MARKER; MUTATION ANALYSIS;

D O I：

10.1002/ijc.24064

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis may contribute to carcinogenesis, tumor progression and also to treatment resistance, since most current anticancer therapies including chemotherapy, radio- and immunotherapy primarily act by activating cell death pathways including apoptosis in cancer cells. Hence, a better understanding of the molecular mechanisms underlying tumor resistance to apoptotic cell death is expected to provide the basis for a rational approach to develop molecular targeted therapies. (C) 2008 Wiley-Liss, Inc.

引用

收藏

页码：511 / 515

页数：5

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