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Role of neurotrophic factors in neuronal development

被引：266
作者：
Henderson, CE
机构：
[1] INSERM U.382, Devmtl. Biol. Institute of Marseille, CNRS-INSERM Univ. de la Mediter., 13288 Marseille Cedex 09
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1996年 / 6卷 / 01期
关键词：
D O I：
10.1016/S0959-4388(96)80010-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The spectrum of potential biological roles for neurotrophic factors in development and maturation of the nervous system continues to widen. Careful analysis of the phenotypes of knock-out mice has been used to test directly the 'neurotrophic hypothesis', and the role of members of the transforming growth factor beta superfamily - in particular, glial cell line derived neurotrophic factor - in regulating neuronal survival has become apparent. The effects of neurotrophin-3 on early neuronal differentiation and maturation have proved to be both multiple and complex. Neurotrophic factors are also emerging as potential regulators of synapse stabilization and function.
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页码：64 / 70
页数：7
相关论文
共 62 条
  • [11] NGF RECEPTOR EXPRESSION IN SENSORY NEURONS DEVELOPS NORMALLY IN EMBRYOS LACKING NGF
    DAVIES, AM
    WYATT, S
    NISHIMURA, M
    PHILLIPS, H
    [J]. DEVELOPMENTAL BIOLOGY, 1995, 171 (02) : 434 - 438
  • [12] DEVELOPMENTAL-CHANGES IN NT3 SIGNALING VIA TRKA AND TRKB IN EMBRYONIC NEURONS
    DAVIES, AM
    MINICHIELLO, L
    KLEIN, R
    [J]. EMBO JOURNAL, 1995, 14 (18) : 4482 - 4489
  • [13] THE ROLE OF NEUROTROPHINS IN THE DEVELOPING NERVOUS-SYSTEM
    DAVIES, AM
    [J]. JOURNAL OF NEUROBIOLOGY, 1994, 25 (11): : 1334 - 1348
  • [14] NEUROTROPHIC FACTORS - SWITCHING NEUROTROPHIN DEPENDENCE
    DAVIES, AM
    [J]. CURRENT BIOLOGY, 1994, 4 (03) : 273 - 276
  • [15] MICE LACKING THE CNTF RECEPTOR, UNLIKE MICE LACKING CNTF, EXHIBIT PROFOUND MOTOR-NEURON DEFICITS AT BIRTH
    DECHIARA, TM
    VEJSADA, R
    POUEYMIROU, WT
    ACHESON, A
    SURI, C
    CONOVER, JC
    FRIEDMAN, B
    MCCLAIN, J
    PAN, L
    STAHL, N
    IP, NY
    KATO, A
    YANCOPOULOS, GD
    [J]. CELL, 1995, 83 (02) : 313 - 322
  • [16] BOTH BASIC FIBROBLAST GROWTH-FACTOR AND CILIARY NEUROTROPHIC FACTOR PROMOTE THE RETENTION OF POLYNEURONAL INNERVATION OF DEVELOPING SKELETAL-MUSCLE FIBERS
    ENGLISH, AW
    SCHWARTZ, G
    [J]. DEVELOPMENTAL BIOLOGY, 1995, 169 (01) : 57 - 64
  • [17] LACK OF NEUROTROPHIN-3 LEADS TO DEFICIENCIES IN THE PERIPHERAL NERVOUS-SYSTEM AND LOSS OF LIMB PROPRIOCEPTIVE AFFERENTS
    ERNFORS, P
    LEE, KF
    KUCERA, J
    JAENISCH, R
    [J]. CELL, 1994, 77 (04) : 503 - 512
  • [18] MUSCLE-DERIVED NEUROTROPHIN-4 AS AN ACTIVITY-DEPENDENT TROPHIC SIGNAL FOR ADULT MOTOR-NEURONS
    FUNAKOSHI, H
    BELLUARDO, N
    ARENAS, E
    YAMAMOTO, Y
    CASABONA, A
    PERSSON, H
    IBANEZ, CF
    [J]. SCIENCE, 1995, 268 (5216) : 1495 - 1499
  • [19] GAESE F, 1994, DEVELOPMENT, V120, P1613
  • [20] DISTINCT ROLES FOR BFGF AND NT-3 IN THE REGULATION OF CORTICAL NEUROGENESIS
    GHOSH, A
    GREENBERG, ME
    [J]. NEURON, 1995, 15 (01) : 89 - 103
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