Clinical Management of Filovirus-Infected Patients

被引:42
作者
Clark, Danielle V. [1 ]
Jahrling, Peter B. [1 ]
Lawler, James V. [2 ]
机构
[1] NIAID, NIH, Integrated Res Facil, Ft Detrick, MD USA
[2] USN, Med Res Ctr Frederick, Frederick, MD USA
来源
VIRUSES-BASEL | 2012年 / 4卷 / 09期
关键词
Filoviruses; Ebola; Marburg; Clinical management; Treatment; Outbreak; EBOLA HEMORRHAGIC-FEVER; MARBURG-VIRUS DISEASE; SEVERE SEPSIS; SEPTIC SHOCK; CONGO; OUTBREAK; EPIDEMIC; FEATURES; CARE; ORGANIZATION;
D O I
10.3390/v4091668
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Filovirus infection presents many unique challenges to patient management. Currently no approved treatments are available, and the recommendations for supportive care are not evidence based. The austere clinical settings in which patients often present and the sporadic and at times explosive nature of filovirus outbreaks have effectively limited the information available to evaluate potential management strategies. This review will summarize the management approaches used in filovirus outbreaks and provide recommendations for collecting the information necessary for evaluating and potentially improving patient outcomes in the future.
引用
收藏
页码:1668 / 1686
页数:19
相关论文
共 115 条
[91]  
Outbreak news, 2007, WKLY EPIDEMIOL REC, V82, P329
[92]  
Outbreak news, 2007, Wkly. Epidemiol. Rec, V82, P345
[93]   The natural history of Ebola virus in Africa [J].
Pourrut, X ;
Kumulungui, B ;
Wittmann, T ;
Moussavou, G ;
Délicat, A ;
Yaba, P ;
Nkoghe, D ;
Gonzalez, JP ;
Leroy, EM .
MICROBES AND INFECTION, 2005, 7 (7-8) :1005-1014
[94]  
Revol D., 2003, RED CROSS RED CRESCE, V2, P14
[95]   Unexpected Ebola virus in a tertiary setting: Clinical and epidemiologic aspects [J].
Richards, GA ;
Murphy, S ;
Jobson, R ;
Mer, M ;
Zinman, C ;
Taylor, R ;
Swanepoel, R ;
Duse, A ;
Sharp, G ;
De la Rey, ICJ ;
Kassianides, C .
CRITICAL CARE MEDICINE, 2000, 28 (01) :240-244
[96]   Early goal-directed therapy in the treatment of severe sepsis and septic shock. [J].
Rivers, E ;
Nguyen, B ;
Havstad, S ;
Ressler, J ;
Muzzin, A ;
Knoblich, B ;
Peterson, E ;
Tomlanovich, M .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (19) :1368-1377
[97]   Filovirus Hemorrhagic Fever Outbreak Case Management: A Review of Current and Future Treatment Options [J].
Roddy, Paul ;
Colebunders, Robert ;
Jeffs, Benjamin ;
Palma, Pedro Pablo ;
Van Herp, Michel ;
Borchert, Matthias .
JOURNAL OF INFECTIOUS DISEASES, 2011, 204 :S791-S795
[98]   Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: Determinants of survival [J].
Sadek, RF ;
Khan, AS ;
Stevens, G ;
Peters, CJ ;
Ksiazek, TG .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 :S24-S27
[99]  
Smith D.H., 1978, P INT C EB VIR INF O
[100]  
SMITH DH, 1982, LANCET, V1, P816