3-Aminopyrrolidines via ring rearrangement of 2-aminomethylazetidines. Synthesis of(-)-absouline

被引：56

作者：

Vargas-Sanchez, M ^{[1
]}

Couty, F ^{[1
]}

Evano, G ^{[1
]}

Prim, D ^{[1
]}

Marrot, J ^{[1
]}

机构：

[1] Univ Versailles St Quentin Yvelines, CNRS, UMR 8086, Lab SIRCOB, F-78035 Versailles, France

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 26期

关键词：

D O I：

10.1021/ol052388e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new entry to enantiopure 3-aminopyrrolidines was developed using a boron trifluoride-mediated rearrangement of 2-aminomethylazetidines. The method is quite general and produces rearranged products in good yield regardless of both substitution pattern and relative stereochemistry of the starting material. A concise stereocontrolled synthesis of (-)-absouline was achieved on the basis of this new method.

引用

页码：5861 / 5864

页数：4

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