Stereoselective synthesis of (2S,3S)-3-hydroxy-2-phenylpiperidines, precursors of non-peptidic substance P antagonists

被引:35
作者
Calvez, O [1 ]
Langlois, N [1 ]
机构
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
关键词
D O I
10.1016/S0040-4039(99)01462-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(2S)-N-Boc-3-oxo-2-phenylpiperidine 5 and (2S,3S)-N-Boc-3-hydroxy-2-phenylpiperidine 6, known chiral building blocks for the synthesis of non-peptidic substance P antagonists, were prepared from erythro (2S)-N-benzyl 2-hydroxybenzylpyrrolidine derived from (S)-N-methoxy-N-methylpyroglutamide. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7099 / 7100
页数:2
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