Tolypodiol, an antiinflammatory diterpenoid from the cyanobacterium Tolypothrix nodosa

被引：32

作者：

Prinsep, MR

Thomson, RA

West, ML

Wylie, BL

机构：

[1] UNIV QUEENSLAND,CTR DRUG DESIGN & DEV,BRISBANE,QLD 4072,AUSTRALIA

[2] UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,SANTA BARBARA,CA 93106

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 08期

关键词：

D O I：

10.1021/np9602574

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new diterpenoid, tolypodiol (1), has been isolated from the terrestrial cyanobacterium Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The monoacetate derivative 2 was prepared. Tolypodiol(1) and its monoacetate derivative 2 show potent antiinflammatory activity in the mouse ear edema assay.

引用

页码：786 / 788

页数：3

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