SUV-measurements and patient-specific corrections in pediatric Hodgkin-lymphoma: Is there a benefit for PPV in early response assessment by FDG-PET?

被引：11

作者：

Furth, Christian ^{[1
]}

Meseck, Robert M. ^{[1
]}

Steffen, Ingo G. ^{[1
,2
]}

Schoenberger, Stefan ^{[3
]}

Denecke, Timm ^{[2
]}

Henze, Guenter ^{[4
]}

Hautzel, Hubertus ^{[5
]}

Hofheinz, Frank ^{[6
]}

Grosser, Oliver ^{[1
]}

Hundsdoerfer, Patrick ^{[4
]}

Amthauer, Holger ^{[1
]}

Ruf, Juri ^{[1
]}

机构：

[1] Otto von Guericke Univ Magdeburg AoR, Sch Med, Dept Radiol & Nucl Med, Magdeburg, Germany

[2] Charite, Dept Radiol & Nucl Med, Berlin, Germany

[3] Univ Dusseldorf, Univ Childrens Hosp, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany

[4] Charite, Dept Pediat Oncol Hematol, Berlin, Germany

[5] Univ Dusseldorf, Res Ctr Juelich, Dept Nucl Med KME, Julich, Germany

[6] Helmholtz Ctr Dresden Rossendorf, PET Ctr, Dresden, Germany

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 03期

关键词：

FDG-PET; Hodgkin lymphoma; pediatrics; response assessment; SUV; ROI DEFINITION; FOLLOW-UP; UPTAKE VALUES; F-18-FDG PET; LUNG-CANCER; UTILITY; RECONSTRUCTION; RESOLUTION; THERAPY; IMPACT;

D O I：

10.1002/pbc.24047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background To evaluate the influence of different SUV-measurements and patient-specific corrections thereof on the positive predictive value (PPV) of FDG-PET in pediatric Hodgkin lymphoma (pHL) using SUV-based response assessment. Methods PET-datasets of 33 children [female, n?=?13, male, n?=?20; range of age, 8.017.8 (mean, 15.0) years; follow-up, 44.583.3 (mean 63.0) months] with HL were analyzed retrospectively. PET-scans were obtained baseline (PET1) and after two cycles of chemotherapy (PET2). Within the leading lesion maximal SUV (SUVmax) and mean SUVs were generated by using isocontur-thresholds for different volumes of interest: Absolute, SUV2.5; relative to SUVmax, SUVmean40% to SUVmean70%. Generated SUVs were adjusted to body weight (SUV) and corrected for body surface area (SUV_BSA), patient's blood glucose and a combination thereof. The decrease in SUV or respective derivates thereof between PET1 and PET2 (?SUV) was assessed for response prediction using receiver operating characteristics (ROC)-analysis. Results Three patients had recurrence of disease. ROC-analysis showed the most accurate differentiation of responders and non-responders for ?SUVmax_BSA [AUC, 0.97; P?=?0.0026; sensitivity, 100%; specificity, 93.3%; PPV, 60.0%; negative predictive value (NPV), 100%; accuracy, 93.3%]. However, comparable results were obtained for conventional ?SUVmax-determination (AUC, 0.96; P?=?0.0112; sensitivity, 100%; specificity, 90.0%; PPV, 50.0%; NPV, 100%; accuracy, 90.9%). Threshold-based approaches were less effective or technically not performable in all patients. Conclusions At early response assessment by FDG-PET, patient-specific correction of ?SUVmax by BSA improves PPV without impairment of excellent NPV in pHL. However, it is not statistically superior to simple ?SUVmax-analyses. Larger cohorts are needed to investigate this observation. Pediatr Blood Cancer 2012;59:475480. (c) 2011 Wiley Periodicals, Inc.

引用

页码：475 / 480

页数：6

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