G-Quadruplexes as Tools for Synthetic Biology

被引：5

作者：

Agarwala, Prachi ^{[1
]}

Pandey, Satyaprakash ^{[1
]}

Maiti, Souvik ^{[1
,2
]}

机构：

[1] CSIR Inst Genom & Integrat Biol, Prote & Struct Biol Unit, Delhi 110007, India

[2] CSIR Natl Chem Lab, Pune 411008, Maharashtra, India

来源：

CHEMBIOCHEM | 2013年 / 14卷 / 16期

关键词：

G-quadruplexes; ribozymes; synthetic biology; topology; zipcodes; RNA G-QUADRUPLEX; LOGIC GATES; NRAS PROTOONCOGENE; MOLECULAR DEVICES; GENE-EXPRESSION; DNA; TRANSLATION; PROMOTERS; SEQUENCE; PROTEIN;

D O I：

10.1002/cbic.201300456

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the potential to engineer biological systems, synthetic biology is an emerging field that combines various disciplines of sciences. It encompasses combinations of DNA, RNA and protein modules for constructing desired systems and the rewiring of existing signalling networks. Despite recent advances, this field still lags behind in the artificial reconstruction of cellular processes, and thus demands new modules and switches to create genetic circuits. The widely characterised noncanonical nucleic acid secondary structures, G-quadruplexes are promising candidates to be used as biological modules in synthetic biology. Structural plasticity and functional versatility are significant G-quadruplex traits for its integration into a biological system and for diverse applications in synthetic circuits.

引用

页码：2077 / 2081

页数：5

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