pH dependent multifunctional and multiply-configurable logic gate systems based on small molecule G-quadruplex DNA recognition

被引：24

作者：

Bhowmik, Sudipta ^{[1
,2
]}

Das, Rabindra Nath ^{[2
]}

Parasar, Bibudha ^{[2
]}

Dash, Jyotirmayee ^{[1
,2
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Organ Chem, Kolkata 700032, India

[2] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741252, W Bengal, India

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 18期

关键词：

DISPLACEMENT ASSAY; LIGANDS; COMPUTATION; DEOXYRIBOZYME; CIRCUITS;

D O I：

10.1039/c3cc38888c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A variety of logic operations such as XNOR, NOR, AND, NAND, NOT have been designed with pH as an external modulator by choosing thiazole orange (TO) and a c-kit2 promoter quadruplex as two inputs and fluorescence signals of pyridyl bis-indole amide (PBIA) and TO as two outputs.

引用

页码：1817 / 1819

页数：3

共 31 条

[1] MOLECULAR COMPUTATION OF SOLUTIONS TO COMBINATORIAL PROBLEMS [J].

ADLEMAN, LM .

SCIENCE, 1994, 266 (5187) :1021-1024

[2] Smart molecules at work-mimicking advanced logic operations [J].

Andreasson, Joakim ;

Pischel, Uwe .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) :174-188

[3]

Balasubramanian S, 2006, RSC BIOMOL SCI, pV

[4]

Balzani V., 2003, MOL DEVICES MACHINE

[5] Construction of molecular logic gates with a DNA-cleaving deoxyribozyme [J].

Chen, X ;

Wang, YF ;

Liu, Q ;

Zhang, ZZ ;

Fan, CH ;

He, L .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (11) :1759-1762

[6] The application of DNA and RNA G-quadruplexes to therapeutic medicines [J].

Collie, Gavin W. ;

Parkinson, Gary N. .

CHEMICAL SOCIETY REVIEWS, 2011, 40 (12) :5867-5892

[7] Synthesis of Bis-indole Carboxamides as G-Quadruplex Stabilizing and Inducing Ligands [J].

Dash, Jyotirmayee ;

Das, Rabindra Nath ;

Hegde, Nagaratna ;

Pantos, G. Dan ;

Shirude, Pravin S. ;

Balasubramanian, Shankar .

CHEMISTRY-A EUROPEAN JOURNAL, 2012, 18 (02) :554-564

[8] Synthesis and Binding Studies of Novel Diethynyl-Pyridine Amides with Genomic Promoter DNA G-Quadruplexes [J].

Dash, Jyotirmayee ;

Waller, Zoe A. E. ;

Pantos, G. Dan ;

Balasubramanian, Shankar .

CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (16) :4571-4581

[9] Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-Quadruplexes [J].

Dash, Jyotirmayee ;

Shirude, Pravin S. ;

Hsu, Shang-Te Danny ;

Balasubramanian, Shankar .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (47) :15950-15956

[10] A MOLECULAR PHOTOIONIC AND GATE BASED ON FLUORESCENT SIGNALING [J].

DE SILVA, AP ;

GUNARATNE, HQN ;

MCCOY, CP .

NATURE, 1993, 364 (6432) :42-44

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