Development of vaginal microbicides for the prevention of heterosexual transmission of HIV

被引：55

作者：

Pauwels, R ^{[1
]}

DeClercq, E ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN,REGA INST MED RES,LOUVAIN,BELGIUM

来源：

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY | 1996年 / 11卷 / 03期

关键词：

vaginal microbicides; sexual transmission; virucidal agents; antiviral agents;

D O I：

10.1097/00042560-199603010-00001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Various compounds could be considered to be vaginal microbicides, preventing heterosexual transmission of HIV (i.e., virucidal agents such as nonoxynol 9 and chlorhexidine) and antiviral agents interfering with either virus adsorption/fusion [polyanionic substances such as polysulfates (i.e. PVAS, PAVAS), polysulfonates, polycarboxylates, polyoxometalates and negatively charged albumins], or fusion/uncoating (bicyclams), or reverse transcription [dideoxynucleoside analogues, acyclic nucleoside phosphonates such as PMEA and PMPA, and non-nucleoside reverse transcriptase inhibitors (NNRTIs) such as TIBO, HEPT, and alpha-APA derivatives]. In particular, combination of two or more of these compounds seems to be an attractive approach to interrupt transmission of HIV at different stages of the infectious process.

引用

页码：211 / 221

页数：11

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