Indazole-type alkaloids from the seeds of Nigella glandulifera

被引：22

作者：

Liu, Yu-Ming ^{[1
]}

Jiang, Yu-Hu ^{[1
]}

Liu, Qing-Hua ^{[2
]}

Chen, Bao-Quan ^{[1
]}

机构：

[1] Tianjin Univ Technol, Dept Pharm Engn, Tianjin 300384, Peoples R China

[2] Xinjiang Inst Mat Med, Urumqi 830001, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2013年 / 6卷 / 04期

关键词：

Nigella; Nigella glandulifera; Ranunculaceae; Indazole-type alkaloids; PHARMACOLOGICAL-PROPERTIES; CHEMISTRY;

D O I：

10.1016/j.phytol.2013.07.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two rare indazole-type alkaloids, nigeglapine (1) and nigeglaquine (2) along with one known compound (3), were isolated from the seeds of Nigella glandulifera. Their structures were confirmed on the basis of chemical and spectroscopic methods, mainly NMR (H-1, C-13, HSQC, HMBC and NOESY) and ESI-MS, and comparison with data in the literature. This is the first report of the natural occurrence of glycosylated indazole-type alkaloids. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：556 / 559

页数：4

相关论文

共 17 条

[1]

Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa [J].

Ali, Zulfiqar ;

Ferreira, Daneel ;

Carvalho, Paulo ;

Avery, Mitchell A. ;

Khan, Ikhlas A. .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (06) :1111-1112

[2]

Atta-ur-Rahman Malik S., 1985, TETRAHEDRON LETT, V26, P2759

[3]

BENDAZAC LYSINE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC POTENTIAL IN THE MANAGEMENT OF CATARACTS [J].

BALFOUR, JA ;

CLISSOLD, SP .

DRUGS, 1990, 39 (04) :575-596

[4]

4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase [J].

Boulouard, Michel ;

Schumann-Bard, Pascale ;

Butt-Gueulle, Sabrina ;

Lohou, Elodie ;

Stiebing, Silvia ;

Collot, Valerie ;

Rault, Sylvain .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (11) :3177-3180

[5]

Pharmacological properties of indazole derivatives:: Recent developments [J].

Cerecetto, H ;

Gerpe, A ;

González, M ;

Arán, VJ ;

de Ocáriz, CO .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (10) :869-878

[6]

Cosimo S.D., 2003, DRUG TODAY, V39, P157

[7]

Discovery of a novel and potent human and rat β3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic acid [J].

Harada, H ;

Hirokawa, Y ;

Suzuki, K ;

Hiyama, Y ;

Oue, M ;

Kawashima, H ;

Kato, H ;

Yoshida, N ;

Furutani, Y ;

Kato, S .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (02) :184-198

[8]

A Review of Granisetron, 5-Hydroxytryptamine3 Receptor Antagonists, and Other Antiemetics [J].

Hsu, Eric S. .

AMERICAN JOURNAL OF THERAPEUTICS, 2010, 17 (05) :476-486

[9]

Transdermal Granisetron: A Guide to Its Use in Preventing Nausea and Vomiting Induced by Chemotherapy [J].

Keating, Gillian M. ;

Duggan, Sean T. ;

Curran, Monique P. .

CNS DRUGS, 2012, 26 (09) :787-790

[10]

A new alkaloid and its artificial derivative with an indazole ring from Nigella glandulifera [J].

Liu, YM ;

Yang, JS ;

Liu, QH .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (04) :454-455