Nodal signaling: Cryptic lefty mechanism of antagonism decoded

被引：29

作者：

Branford, WW ^{[1
]}

Yost, HJ ^{[1
]}

机构：

[1] Univ Utah, Ctr Children, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 09期

关键词：

D O I：

10.1016/j.cub.2004.04.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The secreted TGFbeta factor Lefty antagonizes Nodal signaling during vertebrate embryogenesis, but how it does so has been a mystery. Recent analyses have elucidated the molecular mechanisms underlying this function of Lefty.

引用

页码：R341 / R343

页数：3

共 20 条

[1]

Bisgrove BW, 1999, DEVELOPMENT, V126, P3253

[2] Lefty-dependent inhibition of nodal- and Wnt-responsive organizer is essential for normal gene expression gastrulation [J].

Branford, WW ;

Yost, HJ .

CURRENT BIOLOGY, 2002, 12 (24) :2136-2141

[3] Regulation of gut and heart left-right asymmetry by context-dependent interactions between Xenopus Lefty and BMP4 signaling [J].

Branford, WW ;

Essner, JJ ;

Yost, HJ .

DEVELOPMENTAL BIOLOGY, 2000, 223 (02) :291-306

[4] Two modes by which lefty proteins inhibit Nodal signaling [J].

Chen, CH ;

Shen, MM .

CURRENT BIOLOGY, 2004, 14 (07) :618-624

[5] Lefty proteins are long-range inhibitors of squint-mediated nodal signaling [J].

Chen, Y ;

Schier, AF .

CURRENT BIOLOGY, 2002, 12 (24) :2124-2128

[6]

Cheng AMS, 2000, DEVELOPMENT, V127, P1049

[7] Lefty blocks a subset of TGFβ signals by antagonizing EGF-CFC coreceptors [J].

Cheng, SK ;

Olale, F ;

Brivanlou, AH ;

Schier, AF .

PLOS BIOLOGY, 2004, 2 (02) :215-226

[8] EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1 [J].

Cheng, SK ;

Olale, F ;

Bennett, JT ;

Brivanlou, AH ;

Schier, AF .

GENES & DEVELOPMENT, 2003, 17 (01) :31-36

[9] Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos [J].

Meno, C ;

Ito, Y ;

Saijoh, Y ;

Matsuda, Y ;

Tashiro, K ;

Kuhara, S ;

Hamada, H .

GENES TO CELLS, 1997, 2 (08) :513-524

[10] Mouse lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation [J].

Meno, C ;

Gritsman, K ;

Ohishi, S ;

Ohfuji, Y ;

Heckscher, E ;

Mochida, K ;

Shimono, A ;

Kondoh, H ;

Talbot, WS ;

Robertson, EJ ;

Schier, AF ;

Hamada, H .

MOLECULAR CELL, 1999, 4 (03) :287-298

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