Mechanism of fast peptide recognition by SH3 domains

被引：80

作者：

Ahmad, Mazen ^{[1
]}

Gu, Wei ^{[1
]}

Helms, Volkhard ^{[1
]}

机构：

[1] Univ Saarland, Zentrum Bioinformat, D-66041 Saarbrucken, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 40期

关键词：

adaptor domains; hydrophobic dewetting; molecular dynamics simulation; proline-rich motifs; proteins;

D O I：

10.1002/anie.200801856

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The complete pathway of the association of a proline-rich motif to an SH3 domain was probed by molecular dynamics simulations. The results indicate a bimodal binding mechanism, in which nature uses the reduction in dimensionality and hydrophobic dewetting as tools to find a simple solution to a seemingly complicated binding process. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7626 / 7630

页数：5

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