Cachexia: A new definition

被引：1716

作者：

Evans, William J. ^{[1
]}

Morley, John E. ^{[14
]}

Argiles, Josep ^{[3
]}

Bales, Connie ^{[4
]}

Baracos, Vickie ^{[5
]}

Guttridge, Denis ^{[7
]}

Jatoi, Aminah ^{[8
]}

Kalantar-Zadeh, Kamyar ^{[9
]}

Lochs, Herbert ^{[10
]}

Mantovani, Giovanni ^{[11
]}

Marks, Daniel ^{[12
]}

Mitch, William E. ^{[13
]}

Muscaritoli, Maurizio ^{[15
]}

Najand, Armine ^{[16
]}

Ponikowski, Piotr ^{[18
]}

Rossi Fanelli, Filippo ^{[15
]}

Schambelan, Morrie ^{[19
]}

Schols, Annemie ^{[20
]}

Schuster, Michael ^{[21
]}

Thomas, David ^{[22
]}

Wolfe, Robert ^{[23
]}

Anker, Stefan D. ^{[2
]}

Boyce, Amanda ^{[6
]}

Nuckolls, Glen ^{[17
]}

机构：

[1] Univ Arkansas Med Sci, Donald W Reynolds Inst Aging, Cent Arkansas Vet Healthcare Syst, Little Rock, AR 72205 USA

[2] Charite CVK, Berlin, Germany

[3] Univ Barcelona, Barcelona, Spain

[4] Duke Univ, Durham, NC USA

[5] Univ Alberta, Edmonton, AB, Canada

[6] NIH, Bethesda, MD 20892 USA

[7] Ohio State Univ, Columbus, OH 43210 USA

[8] Mayo Clin, Rochester, MN USA

[9] Harbor UCLA Med Ctr, Los Angeles, CA USA

[10] Charite CCM, Berlin, Germany

[11] Univ Cagliari, Cagliari, Italy

[12] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[13] Baylor Coll Med, Houston, TX 77030 USA

[14] St Louis Univ, St Louis, MO 63103 USA

[15] Univ Roma La Sapienza, Rome, Italy

[16] MEGS, Alpharetta, GA USA

[17] NIH, Bethesda, MD 20892 USA

[18] Clin Mil Hosp, Wroclaw, Poland

[19] Univ Calif San Francisco, Gen Hosp, San Francisco, CA 94143 USA

[20] Univ Hosp, Maastricht, Netherlands

[21] New York Presbytarian, New York, NY USA

[22] St Louis Univ, St Louis, MO 63103 USA

[23] Univ Arkansas, Little Rock, AR 72204 USA

来源：

CLINICAL NUTRITION | 2008年 / 27卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Anorexia; Muscle wasting; Inflammation; Involuntary weight toss; Wasting disease;

D O I：

10.1016/j.clnu.2008.06.013

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

On December 13th and 14th a group of scientists and clinicians met in Washington, DC, for the cachexia consensus conference. At the present time, there is no widely agreed upon operational definition of cachexia. The lack of a definition accepted by clinician and researchers has limited identification and treatment of cachectic patient as well as the development and approval of potential therapeutic agents. The definition that emerged is: "cachexia, is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without toss of fat mass. The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders). Anorexia, inflammation, insulin resistance and increased muscle protein breakdown are frequently associated with cachexia. Cachexia is distinct from starvation, age-related loss of muscle mass, primary depression, malabsorption and hyperthyroidism and is associated with increased morbidity. While this definition has not been tested in epidemiological or intervention studies, a consensus operational definition provides an opportunity for increased research. (C) 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

引用

页码：793 / 799

页数：7

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