Soft lithography: masters on demand

被引：69

作者：

Abdelgawad, Mohamed ^{[2
]}

Watson, Michael W. L. ^{[1
]}

Young, Edmond W. K. ^{[2
,3
]}

Mudrik, Jared M. ^{[1
]}

Ungrin, Mark D. ^{[3
]}

Wheeler, Aaron R. ^{[1
,3
,4
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

[2] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON M5S 3G8, Canada

[3] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

[4] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

来源：

LAB ON A CHIP | 2008年 / 8卷 / 08期

关键词：

D O I：

10.1039/b804050h

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report an ultra-rapid prototyping technique for forming microchannel networks for lab-on-a-chip applications, called masters on-demand. Channels are produced by replica molding on masters formed by laser printing on flexible copper printed circuit board (PCB) substrates. Masters of various designs and dimensions can be individually or mass produced in less than 10 minutes. Using this technique, we have fabricated channels as narrow as 100 mu m with heights ranging between 9 mu m and 70 mu m. Multi-depth channel fabrication is also reported, using a two-step printing process. The functionality of devices formed in this manner is verified by performing in-channel electrophoretic separations and culture and analysis of primary mammalian cells.

引用

页码：1379 / 1385

页数：7

共 42 条

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