Antigen presentation by macrophages harboring intravesicular pathogens

被引：34

作者：

Overath, P ^{[1
]}

Aebischer, T ^{[1
]}

机构：

[1] Max Planck Inst Biol, Abt Membranbiochem, D-72076 Tubingen, Germany

来源：

PARASITOLOGY TODAY | 1999年 / 15卷 / 08期

关键词：

D O I：

10.1016/S0169-4758(99)01473-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Resting macrophages can be host cells for the replication of several protozoan parasites and bacteria. Upon activation, infected cells mobilize potent microbicidal mechanisms that eliminate the intracellular pathogen. This transition from a resting to an activated state is mediated by the interaction with specific T cells that recognize pathogen-derived peptides complexed to major histocompatibility complex (MHC) molecules at the surface of host cells. In this review, Peter Overath and Toni Aebischer discuss antigen presentation in infected macrophages from a cell biological point of view, a perspective that has important implications for the design of subunit vaccines.

引用

页码：325 / 332

页数：8

共 61 条

[21] Stage-specific proteophosphoglycan from Leishmania mexicana amastigotes -: Structural characterization of novel mono-, di-, and triphosphorylated phosphodiester-linked oligosaccharides [J].

Ilg, T ;

Craik, D ;

Currie, G ;

Multhaup, G ;

Bacic, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (22) :13509-13523

[22] THE LYSOSOMAL GP63-RELATED PROTEIN IN LEISHMANIA-MEXICANA AMASTIGOTES IS A SOLUBLE METALLOPROTEINASE WITH AN ACIDIC PH OPTIMUM [J].

ILG, T ;

HARBECKE, D ;

OVERATH, P .

FEBS LETTERS, 1993, 327 (01) :103-107

[23] ISOLATION AND STRUCTURAL CHARACTERIZATION OF THE LEISHMANIA-DONOVANI KINETOPLASTID MEMBRANE PROTEIN-11, A MAJOR IMMUNOREACTIVE MEMBRANE GLYCOPROTEIN [J].

JARDIM, A ;

FUNK, V ;

CAPRIOLI, RM ;

OLAFSON, RW .

BIOCHEMICAL JOURNAL, 1995, 305 :307-313

[24]

Kaufmann SHE, 1998, CHEM IMMUNOL, V70, P21

[25] IMMUNITY TO INTRACELLULAR BACTERIA [J].

KAUFMANN, SHE .

ANNUAL REVIEW OF IMMUNOLOGY, 1993, 11 :129-163

[26] DEFICIENT EXPRESSION OF COSTIMULATORY MOLECULES ON LEISHMANIA-INFECTED MACROPHAGES [J].

KAYE, PM ;

ROGERS, NJ ;

CURRY, AJ ;

SCOTT, JC .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (11) :2850-2854

[27] Leishmania-infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4(+) T cells [J].

Kima, PE ;

Soong, L ;

Chicharro, C ;

Ruddle, NH ;

McMahonPratt, D .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (12) :3163-3169

[28]

LIEW FY, 1990, J IMMUNOL, V145, P4306

[29]

MCCONVILLE MJ, 1991, J BIOL CHEM, V266, P15170

[30] RECOMBINANT VACCINIA VIRUSES EXPRESSING GP46 M-2 PROTECT AGAINST LEISHMANIA INFECTION [J].

MCMAHONPRATT, D ;

RODRIGUEZ, D ;

RODRIGUEZ, JR ;

YA, Z ;

MANSON, K ;

BERGMAN, C ;

RIVAS, L ;

RODRIGUEZ, JF ;

LOHMAN, KL ;

RUDDLE, NH ;

ESTEBAN, M .

INFECTION AND IMMUNITY, 1993, 61 (08) :3351-3359

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