Solid phase synthesis of olefin and hydroxyethylene peptidomimetics

被引：51

作者：

Rotella, DP

机构：

[1] Department of Chemistry, Cephalon, Inc., West Chester, PA 19380

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 48期

关键词：

D O I：

10.1021/ja962290i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：12246 / 12247

页数：2

共 19 条

[1] INHIBITORS OF ASPARTYL PROTEINASES [J].

ABDELMEGUID, SS .

MEDICINAL RESEARCH REVIEWS, 1993, 13 (06) :731-778

[2] DIPEPTIDE ISOSTERES .2. SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERE DIASTEREOMERS FROM A COMMON GAMMA-LACTONE INTERMEDIATE - PREPARATION OF RENIN AND HIV-1 PROTEASE INHIBITOR TRANSITION-STATE MIMICS [J].

BAKER, WR ;

PRATT, JK .

TETRAHEDRON, 1993, 49 (39) :8739-8756

[3] Preparation of aminoalkyl chlorohydrin hydrochlorides: Key building blocks for hydroxyethylamine-based HIV protease inhibitors [J].

Beaulieu, PL ;

Wernic, D .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (11) :3635-3645

[4] A TRANSITION-STATE ANALOG INHIBITOR COMBINATORIAL LIBRARY [J].

CAMPBELL, DA ;

BERMAK, JC ;

BURKOTH, TS ;

PATEL, DV .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (19) :5381-5382

[5] ANALOGOUS ORGANIC-SYNTHESIS OF SMALL-COMPOUND LIBRARIES - VALIDATION OF COMBINATORIAL CHEMISTRY IN SMALL-MOLECULE SYNTHESIS [J].

CHEN, CX ;

RANDALL, LAA ;

MILLER, RB ;

JONES, AD ;

KURTH, MJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (06) :2661-2662

[6] IMPROVED SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE ALDEHYDES [J].

FEHRENTZ, JA ;

PARIS, M ;

HEITZ, A ;

VELEK, J ;

LIU, CF ;

WINTERNITZ, F ;

MARTINEZ, J .

TETRAHEDRON LETTERS, 1995, 36 (43) :7871-7874

[7] S(N)2' RING-OPENING OF AZIRIDINES BEARING AN ALPHA,BETA-UNSATURATED ESTER GROUP WITH ORGANOCOPPER REAGENTS - A NEW STEREOSELECTIVE SYNTHETIC ROUTE TO (E)-ALKENE DIPEPTIDE ISOSTERES [J].

FUJII, N ;

NAKAI, K ;

TAMAMURA, H ;

OTAKA, A ;

MIMURA, N ;

MIWA, Y ;

TAGA, T ;

YAMAMOTO, Y ;

IBUKA, T .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (11) :1359-1371

[8] REAGENT CONTROL IN THE ALDOL ADDITION-REACTION OF CHIRAL BORON ENOLATES WITH CHIRAL ALPHA-AMINO ALDEHYDES - TOTAL SYNTHESIS OF (3S,4S)-STATINE [J].

GENNARI, C ;

PAIN, G ;

MORESCA, D .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (20) :6248-6249

[9] DISCOVERY OF A NOVEL CLASS OF POTENT HIV-1 PROTEASE INHIBITORS CONTAINING THE (R)-(HYDROXYETHYL) UREA ISOSTERE [J].

GETMAN, DP ;

DECRESCENZO, GA ;

HEINTZ, RM ;

REED, KL ;

TALLEY, JJ ;

BRYANT, ML ;

CLARE, M ;

HOUSEMAN, KA ;

MARR, JJ ;

MUELLER, RA ;

VAZQUEZ, ML ;

SHIEH, HS ;

STALLINGS, WC ;

STEGEMAN, RA .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (02) :288-291

[10] A SOLID-PHASE CBZ CHLORIDE EQUIVALENT - A NEW MATRIX SPECIFIC LINKER [J].

HAUSKE, JR ;

DORFF, P .

TETRAHEDRON LETTERS, 1995, 36 (10) :1589-1592

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