MicroRNA: a new frontier in kidney and blood pressure research

被引：85

作者：

Liang, Mingyu ^{[1
]}

Liu, Yong ^{[1
]}

Mladinov, Domagoj ^{[1
]}

Cowley, Allen W., Jr. ^{[1
]}

Trivedi, Hariprasad ^{[2
]}

Fang, Yi ^{[3
]}

Xu, Xialian ^{[3
]}

Ding, Xiaoqiang ^{[3
]}

Tian, Zhongmin ^{[4
]}

机构：

[1] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Div Nephrol, Milwaukee, WI 53226 USA

[3] Fudan Univ, Zhongshan Hosp, Div Nephrol, Shanghai 200433, Peoples R China

[4] Xi An Jiao Tong Univ, Dept Biomed Engn, Shanxi, Peoples R China

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2009年 / 297卷 / 03期

关键词：

hypertension; acute kidney injury; chronic kidney disease; gene; SALT-SENSITIVE HYPERTENSION; GENE-EXPRESSION; POSTTRANSCRIPTIONAL REGULATION; MESENCHYMAL TRANSITION; MICROARRAY ANALYSIS; MAMMALIAN-CELLS; MESSENGER-RNAS; HEART-DISEASE; EMERGING ROLE; HOST GENES;

D O I：

10.1152/ajprenal.00045.2009

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Liang M, Liu Y, Mladinov D, Cowley AW Jr, Trivedi H, Fang Y, Xu X, Ding X, Tian Z. MicroRNA: a new frontier in kidney and blood pressure research. Am J Physiol Renal Physiol 297: F553-F558, 2009. First published April 1, 2009; doi:10.1152/ajprenal.00045.2009.-MicroRNA (miRNA) has emerged rapidly as a major new direction in many fields of research including kidney and blood pressure research. A mammalian genome encodes several hundred miRNAs. These miRNAs potentially regulate the expression of thousands of proteins. miRNA expression profiles differ substantially between the kidney and other organs as well as between kidney regions. miRNAs may be functionally important in models of diabetic nephropathy, podocyte development, and polycystic disease. miRNAs may be involved in the regulation of arterial blood pressure, including possible involvement in genetic elements of hypertension. Studies of miRNAs could generate diagnostic biomarkers for kidney disease and new mechanistic insights into the complex regulatory networks underlying kidney disease and hypertension. Further progress in the understanding of miRNA biogenesis and action and technical improvements for target identification and miRNA manipulation will be important for studying miRNAs in renal function and blood pressure regulation.

引用

页码：F553 / F558

页数：6

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