Metagenomic approaches to natural products from free-living and symbiotic organisms

被引：85

作者：

Brady, Sean F. ^{[1
]}

Simmons, Luke ^{[1
]}

Kim, Jeffrey H. ^{[1
]}

Schmidt, Eric W. ^{[2
]}

机构：

[1] Rockefeller Univ, Lab Genet Encoded Small Mol, New York, NY 10021 USA

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

来源：

NATURAL PRODUCT REPORTS | 2009年 / 26卷 / 11期

关键词：

CANDIDATUS-ENDOBUGULA-SERTULA; BRYOZOAN BUGULA-NERITINA; POLYKETIDE SYNTHASE GENES; UNCULTIVATED BACTERIAL SYMBIONTS; ASCIDIAN LISSOCLINUM-PATELLA; TUNICATE SYNOICUM-ADAREANUM; SPONGE THEONELLA-SWINHOEI; 4 DICTYOCERATID SPONGES; SOIL DNA LIBRARIES; ENVIRONMENTAL DNA;

D O I：

10.1039/b817078a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial cultivation has been a mainstay of natural products discovery for the past 80 years. However, the majority of bacteria are recalcitrant to culture, providing an untapped source for new natural products. Metagenomic analysis provides an alternative method to directly access the uncultivated genome for natural products research and for the discovery of novel, bioactive substances. Applications of metagenomics to diverse habitats, such as soils and the interior of animals, are described.

引用

页码：1488 / 1503

页数：16

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