Metagenomics and industrial applications

被引：313

作者：

Lorenz, P ^{[1
]}

Eck, J ^{[1
]}

机构：

[1] BRAIN AG, D-64673 Zwingenberg, Germany

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 06期

关键词：

D O I：

10.1038/nrmicro1161

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Different industries have different motivations to probe the enormous resource that is uncultivated microbial diversity. Currently, there is a global political drive to promote white (industrial) biotechnology as a central feature of the sustainable economic future of modern industrialized societies. This requires the development of novel enzymes, processes, products and applications. Metagenomics promises to provide new molecules with diverse functions, but ultimately, expression systems are required for any new enzymes and bioactive molecules to become an economic success. This review highlights industrial efforts and achievements in metagenomics.

引用

页码：510 / 516

页数：7

共 75 条

[1] [Anonymous], 2001, APPL BIOT IND SUST
[2] Isolation of high molecular weight DNA from soil for cloning into BAC vectors
Berry, AE
Chiocchini, C
Selby, T
Sosio, M
Wellington, EMH
[J]. FEMS MICROBIOLOGY LETTERS, 2003, 223 (01) : 15 - 20
[3] Long-chain N-acyltyrosine synthases from environmental DNA
Brady, SF
Chao, CJ
Clardy, J
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 70 (11) : 6865 - 6870
[4] BREVES R, 2003, Patent No. 03054177
[5] The search for the ideal biocatalyst
Burton, SG
Cowan, DA
Woodley, JM
[J]. NATURE BIOTECHNOLOGY, 2002, 20 (01) : 37 - 45
[6] Cottrell MT, 1999, APPL ENVIRON MICROB, V65, P2553
[7] Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products
Courtois, S
Cappellano, CM
Ball, M
Francou, FX
Normand, P
Helynck, G
Martinez, A
Kolvek, SJ
Hopke, J
Osburne, MS
August, PR
Nalin, R
Guérineau, M
Jeannin, P
Simonet, P
Pernodet, JL
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2003, 69 (01) : 49 - 55
[8] Medicinals for the millennia - The historical record
Cragg, GM
Newman, DJ
[J]. NEW VISTAS IN THERAPEUTICS, FROM DRUG DESIGN TO GENE THERAPY: DRUG-RESISTANT TUBERCULOSIS, FROM MOLECULES TO MACRO-ECONOMICS, 2001, 953 : 3 - 25
[9] Estimating prokaryotic diversity and its limits
Curtis, TP
Sloan, WT
Scannell, JW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (16) : 10494 - 10499
[10] The soil metagenome - a rich resource for the discovery of novel natural products
Daniel, R
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 2004, 15 (03) : 199 - 204

← 1 2 3 4 5 6 7 8 →