Nickel(0)/NaHMDS adduct-mediated intramolecular alkylation of unactivated arenes via a homolytic aromatic substitution mechanism

被引：26

作者：

Beaulieu, Louis-Philippe B. ^{[1
]}

Roman, Daniela Sustac ^{[1
]}

Vallee, Frederic ^{[1
]}

Charette, Andre B. ^{[1
]}

机构：

[1] Univ Montreal, FRQNT Ctr Green Chem & Catalysis, Dept Chem, Stn Downtown, Montreal, PQ H3C 3J7, Canada

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 66期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

CATALYZED DIRECT ARYLATION; POTASSIUM TERT-BUTOXIDE; C-H ACTIVATION; ARYL HALIDES; RADICAL ISOMERIZATION; COUPLING REACTIONS; IPSO SUBSTITUTION; TRANSLOCATION; COMPLEXES; NITROGEN;

D O I：

10.1039/c2cc33547f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A variety of polycycles can be synthesized via an intramolecular alkylation cyclization promoted by Ni(PPh3)(4) and NaHMDS. Mechanistic investigations support the catalytic nature of Ni-0 in the course of TEMPO scavenging experiments and its association with the substrate and NaHMDS to form an adduct by DOSY NMR.

引用

页码：8249 / 8251

页数：3

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