A functional nitric oxide reductase model

被引：85

作者：

Collman, James P. ^{[1
]}

Yang, Ying ^{[1
]}

Dey, Abhishek ^{[1
]}

Decreau, Richard A. ^{[1
]}

Ghosh, Somdatta ^{[1
]}

Ohta, Takehiro ^{[1
]}

Solomon, Edward I. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 41期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

functional model; NO reduction; N2O; trans" mechanism;

D O I：

10.1073/pnas.0808606105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A functional heme/nonheme nitric oxide reductase (NOR) model is presented. The fully reduced diiron compound reacts with two equivalents of NO leading to the formation of one equivalent of N2O and the bis-ferric product. NO binds to both heme Fe and nonheme Fe complexes forming individual ferrous nitrosyl species. The mixed-valence species with an oxidized heme and a reduced nonheme Fe-B does not show NO reduction activity. These results are consistent with a so-called "trans" mechanism for the reduction of NO by bacterial NOR.

引用

收藏

页码：15660 / 15665

页数：6

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