Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella

被引：39

作者：

Gunasekera, SP ^{[1
]}

McCarthy, PJ ^{[1
]}

Longley, RE ^{[1
]}

Pomponi, SA ^{[1
]}

Wright, AE ^{[1
]}

机构：

[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 08期

关键词：

D O I：

10.1021/np990177a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Secobatzelline A (1), a new batzelline natural analogue, and secobatzelline B (2), a likely artifact formed during the isolation procedure, have been isolated from a deep-water marine sponge of the genus Batzella. Secobatzellines A and B inhibited the phosphatase activity of calcineurin, and secobatzelline A inhibited the peptidase activity of CPP32. Both compounds showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of secobatzellines A (1) and B (2) are described.

引用

页码：1208 / 1211

页数：4

共 27 条

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