New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells

被引：10

作者：

Alonso, MM

Encío, I

Martínez-Merino, V

Gil, M

Migliaccio, M

机构：

[1] Publ Univ Navarra, Dept Hlth Sci, Pamplona 31008, Spain

[2] Publ Univ Navarra, Dept Appl Chem, Pamplona 31006, Spain

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 85卷 / 09期

关键词：

diarylsulfonylureas; antineoplasic drugs; NADH oxidase; CCRF-CEM; plasma membrane;

D O I：

10.1054/bjoc.2001.2083

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A series of benzo(b)thiophenesulfonamide 1,1-dioxide derivatives (13TS) have been designed and synthesized as candidate antineoplastic drugs. Several of these compounds have shown in vitro cytotoxic activity on leukaemic CCRF-CEM cells. The cytotoxic BTS, but not the inactive ones, were able to inhibit a tumour cell-specific NADH oxidase activity present in the membrane of CCRF-CEM cells. (C) 2001 Cancer Research Campaign.

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收藏

页码：1400 / 1402

页数：3

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