Immune-microbiota interactions in health and disease

被引：223

作者：

Palm, Noah W. ^{[1
,3
]}

de Zoete, Marcel R. ^{[1
,2
,3
]}

Flavell, Richard A. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Anlyan Ctr, Dept Immunobiol, New Haven, CT 06519 USA

来源：

CLINICAL IMMUNOLOGY | 2015年 / 159卷 / 02期

关键词：

Microbiota; Adaptive immunity; T cells; Immunoglobulin A; Commensals; Inflammation; SEGMENTED FILAMENTOUS BACTERIA; INNATE LYMPHOID-CELLS; FOXP3(+) T-CELLS; INTESTINAL INFLAMMATION; GUT MICROBIOTA; COMMENSAL MICROBIOTA; SYMBIOTIC BACTERIA; METABOLIC SYNDROME; T(H)17 CELLS; IGA RESPONSE;

D O I：

10.1016/j.clim.2015.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have revealed that the intestinal microbiota plays an important role in host physiology and pathphysiology in health and disease. One of the major mechanisms by which the gut microbiota influences the host is through its interactions with and effects on the host immune system. In this review, we discuss the reciprocal interactions between the host immune system and the gut microbiota, with a particular focus on individual microbes that impact the host through dramatic and specific interactions with the adaptive immune system. We highlight the idea that the presence or absence of specific immunologically important members of the microbiota can determine disease susceptibility and propose that the identification and characterization of these bacteria in humans will eventually allow us to elucidate the role of microbiota composition in human disease. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：122 / 127

页数：6

共 79 条

[1] Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells [J].

An, Dingding ;

Oh, Sungwhan F. ;

Olszak, Torsten ;

Neves, Joana F. ;

Avci, Fikri Y. ;

Erturk-Hasdemir, Deniz ;

Lu, Xi ;

Zeissig, Sebastian ;

Blumberg, Richard S. ;

Kasper, Dennis L. .

CELL, 2014, 156 (1-2) :123-133

[2] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[3] Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Oshima, Kenshiro ;

Suda, Wataru ;

Nagano, Yuji ;

Nishikawa, Hiroyoshi ;

Fukuda, Shinji ;

Saito, Takuro ;

Narushima, Seiko ;

Hase, Koji ;

Kim, Sangwan ;

Fritz, Joelle V. ;

Wilmes, Paul ;

Ueha, Satoshi ;

Matsushima, Kouji ;

Ohno, Hiroshi ;

Olle, Bernat ;

Sakaguchi, Shimon ;

Taniguchi, Tadatsugu ;

Morita, Hidetoshi ;

Hattori, Masahira ;

Honda, Kenya .

NATURE, 2013, 500 (7461) :232-+

[4] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[5] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[6] Microbiota, Disease, and Back to Health: A Metastable Journey [J].

Blumberg, Richard ;

Powrie, Fiona .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (137)

[7] Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis [J].

Bouskra, Djahida ;

Brezillon, Christophe ;

Berard, Marion ;

Werts, Catherine ;

Varona, Rosa ;

Boneca, Ivo Gomperts ;

Eberl, Gerard .

NATURE, 2008, 456 (7221) :507-U34

[8] Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota [J].

Brown, Laura C. Wieland ;

Penaranda, Cristina ;

Kashyap, Purna C. ;

Williams, Brianna B. ;

Clardy, Jon ;

Kronenberg, Mitchell ;

Sonnenburg, Justin L. ;

Comstock, Laurie E. ;

Bluestone, Jeffrey A. ;

Fischbach, Michael A. .

PLOS BIOLOGY, 2013, 11 (07)

[9] Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice [J].

Carvalho, Frederic A. ;

Koren, Omry ;

Goodrich, Julia K. ;

Johansson, Malin E. V. ;

Nalbantoglu, Ilke ;

Aitken, Jesse D. ;

Su, Yueju ;

Chassaing, Benoit ;

Walters, William A. ;

Gonzalez, Antonio ;

Clemente, Jose C. ;

Cullender, Tyler C. ;

Barnich, Nicolas ;

Darfeuille-Michaud, Arlette ;

Vijay-Kumar, Matam ;

Knight, Rob ;

Ley, Ruth E. ;

Gewirtz, Andrew T. .

CELL HOST & MICROBE, 2012, 12 (02) :139-152

[10] Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice [J].

Chassaing, Benoit ;

Ley, Ruth E. ;

Gewirtz, Andrew T. .

GASTROENTEROLOGY, 2014, 147 (06) :1363-+

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