Immune-microbiota interactions in health and disease

被引：223

作者：

Palm, Noah W. ^{[1
,3
]}

de Zoete, Marcel R. ^{[1
,2
,3
]}

Flavell, Richard A. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Anlyan Ctr, Dept Immunobiol, New Haven, CT 06519 USA

来源：

CLINICAL IMMUNOLOGY | 2015年 / 159卷 / 02期

关键词：

Microbiota; Adaptive immunity; T cells; Immunoglobulin A; Commensals; Inflammation; SEGMENTED FILAMENTOUS BACTERIA; INNATE LYMPHOID-CELLS; FOXP3(+) T-CELLS; INTESTINAL INFLAMMATION; GUT MICROBIOTA; COMMENSAL MICROBIOTA; SYMBIOTIC BACTERIA; METABOLIC SYNDROME; T(H)17 CELLS; IGA RESPONSE;

D O I：

10.1016/j.clim.2015.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have revealed that the intestinal microbiota plays an important role in host physiology and pathphysiology in health and disease. One of the major mechanisms by which the gut microbiota influences the host is through its interactions with and effects on the host immune system. In this review, we discuss the reciprocal interactions between the host immune system and the gut microbiota, with a particular focus on individual microbes that impact the host through dramatic and specific interactions with the adaptive immune system. We highlight the idea that the presence or absence of specific immunologically important members of the microbiota can determine disease susceptibility and propose that the identification and characterization of these bacteria in humans will eventually allow us to elucidate the role of microbiota composition in human disease. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：122 / 127

页数：6

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