Microbiota, Disease, and Back to Health: A Metastable Journey

被引：235

作者：

Blumberg, Richard ^{[1
]}

Powrie, Fiona ^{[2
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Gastroenterol Div,Dept Med, Boston, MA 02115 USA

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Translat Gastroenterol Unit,Expt Med Div, Oxford OX3 9DU, England

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 137期

基金：

英国惠康基金;

关键词：

INFLAMMATORY BOWEL DISEASES; GUT MICROBIOTA; CLOSTRIDIUM-DIFFICILE; BACTEROIDES-FRAGILIS; INTESTINAL MICROBIOTA; COMMENSAL BACTERIA; IMMUNE-SYSTEM; MOUSE; MICE; PROMOTES;

D O I：

10.1126/scitranslmed.3004184

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alterations in the composition of the commensal microbiota have been observed in many complex diseases. Understanding the basis for these changes, how they relate to disease risk or activity, and the mechanisms by which the symbiotic state of colonization resistance and host homeostasis is restored is critical for future therapies aimed at manipulating the microbiota.

引用

页数：9

共 94 条

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