Finding function in novel targets:: C-elegans as a model organism

被引：756

作者：

Kaletta, T

Hengartner, MO

机构：

[1] Devgen, B-9052 Ghent, Belgium

[2] Univ Zurich, Inst Mol Biol, CH-8057 Zurich, Switzerland

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 05期

关键词：

D O I：

10.1038/nrd2031

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Despite its apparent simplicity, the nematode worm Caenorhabditis elegans has developed into an important model for biomedical research, particularly in the functional characterization of novel drug targets that have been identified using genomics technologies. The cellular complexity and the conservation of disease pathways between C. elegans and higher organisms, together with the simplicity and cost-effectiveness of cultivation, make for an effective in vivo model that is amenable to whole-organism high-throughput compound screens and large-scale target validation. This review describes how C. elegans models can be used to advance our understanding of the molecular mechanisms of drug action and disease pathogenesis.

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收藏

页码：387 / 398

页数：12

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