Estimating the Genetic Variance of Major Depressive Disorder Due to All Single Nucleotide Polymorphisms

被引：102

作者：

Lubke, Gitta H. ^{[1
,2
]}

Hottenga, Jouke Jan ^{[2
]}

Walters, Raymond ^{[1
]}

Laurin, Charles ^{[1
]}

de Geus, Eco J. C. ^{[2
]}

Willemsen, Gonneke ^{[1
]}

Smit, Jan H. ^{[2
]}

Middeldorp, Christel M. ^{[2
,3
,4
]}

Penninx, Brenda W. J. H. ^{[3
]}

Vink, Jacqueline M. ^{[2
]}

Boomsma, Dorret I. ^{[2
]}

机构：

[1] Univ Notre Dame, Dept Psychol, Notre Dame, IN 46556 USA

[2] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

来源：

BIOLOGICAL PSYCHIATRY | 2012年 / 72卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Fasting glucose; genome-wide association studies (GWAS); genome-wide complex trait analysis (GCTA); height; major depressive disorder (MDD); missing heritability; smoking; SUSCEPTIBILITY VARIANTS; QUALITY-CONTROL; HERITABILITY;

D O I：

10.1016/j.biopsych.2012.03.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-wide association studies of major depressive disorder in particular have so far been unsuccessful in detecting genome-wide significant single nucleotide polymorphisms (SNPs). Using two recently proposed methods designed to estimate the heritability of a phenotype that is attributable to genome-wide SNPs, we show that SNPs on current platforms contain substantial information concerning the additive genetic variance of major depressive disorder. To assess the consistency of these two methods, we analyzed four other complex phenotypes from different domains. The pattern of results is consistent with estimates of heritability obtained in twin studies carried out in the same population.

引用

页码：707 / 709

页数：3

共 18 条

[1] Data quality control in genetic case-control association studies [J].

Anderson, Carl A. ;

Pettersson, Fredrik H. ;

Clarke, Geraldine M. ;

Cardon, Lon R. ;

Morris, Andrew P. ;

Zondervan, Krina T. .

NATURE PROTOCOLS, 2010, 5 (09) :1564-1573

[2] Genetic risk profiles for depression and anxiety in adult and elderly cohorts [J].

Demirkan, A. ;

Penninx, B. W. J. H. ;

Hek, K. ;

Wray, N. R. ;

Amin, N. ;

Aulchenko, Y. S. ;

van Dyck, R. ;

de Geus, E. J. C. ;

Hofman, A. ;

Uitterlinden, A. G. ;

Hottenga, J-J ;

Nolen, W. A. ;

Oostra, B. A. ;

Sullivan, P. F. ;

Willemsen, G. ;

Zitman, F. G. ;

Tiemeier, H. ;

Janssens, A. C. J. W. ;

Boomsma, D. I. ;

van Duijn, C. M. ;

Middeldorp, C. M. .

MOLECULAR PSYCHIATRY, 2011, 16 (07) :773-783

[3] Schizophrenia Genetics: Where Next? [J].

Kim, Yunjung ;

Zerwas, Stephanie ;

Trace, Sara E. ;

Sullivan, Patrick F. .

SCHIZOPHRENIA BULLETIN, 2011, 37 (03) :456-463

[4] Estimating Missing Heritability for Disease from Genome-wide Association Studies [J].

Lee, Sang Hong ;

Wray, Naomi R. ;

Goddard, Michael E. ;

Visscher, Peter M. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2011, 88 (03) :294-305

[5] A Simple and Fast Two-Locus Quality Control Test to Detect False Positives Due to Batch Effects in Genome-Wide Association Studies [J].

Lee, Sang Hong ;

Nyholt, Dale R. ;

Macgregor, Stuart ;

Henders, Anjali K. ;

Zondervan, Krina T. ;

Montgomery, Grant W. ;

Visscher, Peter M. .

GENETIC EPIDEMIOLOGY, 2010, 34 (08) :854-862

[6] Finding the missing heritability of complex diseases [J].

Manolio, Teri A. ;

Collins, Francis S. ;

Cox, Nancy J. ;

Goldstein, David B. ;

Hindorff, Lucia A. ;

Hunter, David J. ;

McCarthy, Mark I. ;

Ramos, Erin M. ;

Cardon, Lon R. ;

Chakravarti, Aravinda ;

Cho, Judy H. ;

Guttmacher, Alan E. ;

Kong, Augustine ;

Kruglyak, Leonid ;

Mardis, Elaine ;

Rotimi, Charles N. ;

Slatkin, Montgomery ;

Valle, David ;

Whittemore, Alice S. ;

Boehnke, Michael ;

Clark, Andrew G. ;

Eichler, Evan E. ;

Gibson, Greg ;

Haines, Jonathan L. ;

Mackay, Trudy F. C. ;

McCarroll, Steven A. ;

Visscher, Peter M. .

NATURE, 2009, 461 (7265) :747-753

[7] Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings [J].

Middeldorp, CM ;

Birley, AJ ;

Cath, DC ;

Gillespie, NA ;

Willemsen, G ;

Statham, DJ ;

de Geus, EJC ;

Andrews, JG ;

van Dyck, R ;

Beem, AL ;

Sullivan, PF ;

Martin, NG ;

Boomsma, DI .

TWIN RESEARCH AND HUMAN GENETICS, 2005, 8 (06) :609-615

[8] The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods [J].

Penninx, Brenda W. J. H. ;

Beekman, Aartjan T. F. ;

Smit, Johannes H. ;

Zitman, Frans G. ;

Nolen, Willem A. ;

Spinhoven, Philip ;

Cuijpers, Pim ;

De Jong, Peter J. ;

Van Marwijk, Harm W. J. ;

Assendelft, Willem J. J. ;

Van Der Meer, Klaas ;

Verhaak, Peter ;

Wensing, Michel ;

De Graaf, Ron ;

Hoogendijk, Witte J. ;

Ormel, Johan ;

Van Dyck, Richard .

INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, 2008, 17 (03) :121-140

[9] Common polygenic variation contributes to risk of schizophrenia and bipolar disorder [J].

Purcell, Shaun M. ;

Wray, Naomi R. ;

Stone, Jennifer L. ;

Visscher, Peter M. ;

O'Donovan, Michael C. ;

Sullivan, Patrick F. ;

Sklar, Pamela ;

Ruderfer, Douglas M. ;

McQuillin, Andrew ;

Morris, Derek W. ;

O'Dushlaine, Colm T. ;

Corvin, Aiden ;

Holmans, Peter A. ;

Macgregor, Stuart ;

Gurling, Hugh ;

Blackwood, Douglas H. R. ;

Craddock, Nick J. ;

Gill, Michael ;

Hultman, Christina M. ;

Kirov, George K. ;

Lichtenstein, Paul ;

Muir, Walter J. ;

Owen, Michael J. ;

Pato, Carlos N. ;

Scolnick, Edward M. ;

St Clair, David ;

Williams, Nigel M. ;

Georgieva, Lyudmila ;

Nikolov, Ivan ;

Norton, N. ;

Williams, H. ;

Toncheva, Draga ;

Milanova, Vihra ;

Thelander, Emma F. ;

Sullivan, Patrick ;

Kenny, Elaine ;

Quinn, Emma M. ;

Choudhury, Khalid ;

Datta, Susmita ;

Pimm, Jonathan ;

Thirumalai, Srinivasa ;

Puri, Vinay ;

Krasucki, Robert ;

Lawrence, Jacob ;

Quested, Digby ;

Bass, Nicholas ;

Crombie, Caroline ;

Fraser, Gillian ;

Kuan, Soh Leh ;

Walker, Nicholas .

NATURE, 2009, 460 (7256) :748-752

[10]

Silventoinen K, 2003, TWIN RES, V6, P399, DOI 10.1375/twin.6.5.399

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