Enantioselective Michael reactions promoted by recoverable dimeric anthryl-derived Cinchona phase-transfer catalysts

被引:23
作者
Chinchilla, R
Mazón, P
Nájera, C
Ortega, FJ
Yus, M
机构
[1] Univ Alicante, Dept Quim Organ, Apartado 99, E-03080 Alicante, Spain
[2] Univ Alicante, Inst Sintesis Organ, E-03080 Alicante, Spain
关键词
asymmetric synthesis; ammonium salts; phase-transfer catalysis; Michael addition; amino acids;
D O I
10.3998/ark.5550190.0006.619
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Dimeric cinchonidine and cinchonine-derived ammonium salts have been used as phase transfer catalysts in the Michael addition reaction of N-(diphenylmethylene) glycine tert-butyl ester to electron-poor olefins. The enantioselectivity of the reaction (up to 97% ee) was dependent of the counter-anion present in the ammonium salt, and the catalysts could be recovered by precipitation.
引用
收藏
页码:222 / 232
页数:11
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