Enantioselective Michael reactions promoted by recoverable dimeric anthryl-derived Cinchona phase-transfer catalysts

被引：23

作者：

Chinchilla, R

Mazón, P

Nájera, C

Ortega, FJ

Yus, M

机构：

[1] Univ Alicante, Dept Quim Organ, Apartado 99, E-03080 Alicante, Spain

[2] Univ Alicante, Inst Sintesis Organ, E-03080 Alicante, Spain

来源：

ARKIVOC | 2005年

关键词：

asymmetric synthesis; ammonium salts; phase-transfer catalysis; Michael addition; amino acids;

D O I：

10.3998/ark.5550190.0006.619

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dimeric cinchonidine and cinchonine-derived ammonium salts have been used as phase transfer catalysts in the Michael addition reaction of N-(diphenylmethylene) glycine tert-butyl ester to electron-poor olefins. The enantioselectivity of the reaction (up to 97% ee) was dependent of the counter-anion present in the ammonium salt, and the catalysts could be recovered by precipitation.

引用

页码：222 / 232

页数：11

共 93 条

[81] Development of new asymmetric two-center catalysts in phase-transfer reactions [J].