Development of new asymmetric two-center catalysts in phase-transfer reactions

被引：145

作者：

Shibuguchi, T ^{[1
]}

Fukuta, Y ^{[1
]}

Akachi, Y ^{[1
]}

Sekine, A ^{[1
]}

Ohshima, T ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 52期

基金：

日本学术振兴会;

关键词：

phase-transfer catalysis; asymmetric two-center catalyst; alkylation; Michael addition;

D O I：

10.1016/S0040-4039(02)02416-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new asymmetric two-center phase-transfer catalyst was designed and a catalyst library containing more than 40 new two-center catalysts was constructed. The catalysts were applied in phase-transfer alkylations and Michael additions to afford the corresponding products in up to 93% ee and 82% ee, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：9539 / 9543

页数：5

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