Characterization of the human MDR1 gene

被引：80

作者：

Bodor, M ^{[1
]}

Kelly, EJ ^{[1
]}

Ho, RJ ^{[1
]}

机构：

[1] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA

来源：

AAPS JOURNAL | 2005年 / 7卷 / 01期

关键词：

MDR1; gene; P-glycoprotein; gene arrangements;

D O I：

10.1208/aapsj070101

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

P-glycoprotein ( Pgp), an ATP-dependent efflux transporter that protects the body from environmental toxins and xenobiotics, is encoded by the human MDR1 gene. Human MDR1 is located on chromosomal region 7q21. Although several different single nucleotide polymorphisms were shown to influence Pgp expression and activity, the reported length of the MDR1 gene in Genbank and other databases continues to evolve and varies between 6.3 kilobases ( kb) and 210 kb. With DNA derived from human cell lines and tissues, we have characterized the MDR1 genomic sequence to be 209 kb.

引用

页码：E1 / E5

页数：5

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