The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase

被引：64

作者：

Iikubo, K

Ishikawa, Y

Ando, N

Umezawa, K

Nishiyama, S

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 02期

关键词：

Garcinia mangostana L; alpha-mangostin; acidic sphingomyelinase; apoptosis;

D O I：

10.1016/S0040-4039(01)02137-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of alpha-mangostin 1a has been achieved. The key cyclization reaction to construct the xanthone framework was undertaken by employing the PPh3-CCl4 conditions. The inhibitory activities of 1a and the benzophenone intermediate 16 against the acidic sphingonlyelinase were discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：291 / 293

页数：3

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