EIN2-Directed Translational Regulation of Ethylene Signaling in Arabidopsis

被引：301

作者：

Li, Wenyang ^{[1
]}

Ma, Mengdi ^{[1
]}

Feng, Ying ^{[1
]}

Li, Hongjiang ^{[1
]}

Wang, Yichuan ^{[1
]}

Ma, Yutong ^{[1
]}

Li, Mingzhe ^{[1
]}

An, Fengying ^{[1
,2
]}

Guo, Hongwei ^{[1
,2
]}

机构：

[1] Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China

[2] Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

来源：

CELL | 2015年 / 163卷 / 03期

基金：

中国国家自然科学基金;

关键词：

F-BOX PROTEINS; RESPONSE PATHWAY; ENDOPLASMIC-RETICULUM; TRANSDUCTION PATHWAY; CERNA HYPOTHESIS; RNA DECAY; EIN2; HORMONE; GAS; CTR1;

D O I：

10.1016/j.cell.2015.09.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ethylene is a gaseous phytohormone that plays vital roles in plant growth and development. Previous studies uncovered EIN2 as an essential signal transducer linking ethylene perception on ER to transcriptional regulation in the nucleus through a "cleave and shuttle'' model. In this study, we report another mechanism of EIN2-mediated ethylene signaling, whereby EIN2 imposes the translational repression of EBF1 and EBF2 mRNA. We find that the EBF1/2 3' UTRs mediate EIN2-directed translational repression and identify multiple poly-uridylates (PolyU) motifs as functional cis elements of 3' UTRs. Furthermore, we demonstrate that ethylene induces EIN2 to associate with 3' UTRs and target EBF1/2 mRNA to cytoplasmic processing-body (P-body) through interacting with multiple P-body factors, including EIN5 and PABs. Our study illustrates translational regulation as a key step in ethylene signaling and presents mRNA 3' UTR functioning as a "signal transducer'' to sense and relay cellular signaling in plants.

引用

页码：670 / 683

页数：14

共 42 条

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