Cobalt(II)-Catalyzed cross-coupling between polyfunctional arylcopper reagents and aryl fluorides or tosylates

被引:110
作者
Korn, TJ [1 ]
Schade, MA [1 ]
Wirth, S [1 ]
Knochel, P [1 ]
机构
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
关键词
D O I
10.1021/ol0529142
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Organocopper compounds prepared by the transmetalation of functionalized arylmagnesium halides with CuCN-2LiCl undergo smooth cross-coupling reactions with aryl fluorides and tosylates bearing a carbonyl function in the ortho position in the presence of Co(acac)(2) (7.5 mol%), Bu(4)Nl (1 equiv), and 4-fluorostyrene (20 mol %) as promoters in DME/THF/DMPU leading to polyfunctional aromatics or heterocycles.
引用
收藏
页码:725 / 728
页数:4
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