Target validation of G-protein coupled receptors

被引：306

作者：

Wise, A ^{[1
]}

Gearing, K ^{[1
]}

Rees, S ^{[1
]}

机构：

[1] GlaxoSmithKline, Mol Screening Dept, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 04期

关键词：

D O I：

10.1016/S1359-6446(01)02131-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

G-protein coupled receptors (GPCRs) represent possibly the most important target class of proteins for drug discovery. Over 30% of clinically marketed drugs are active at this receptor family. These drugs exhibit their activity at <10% of all known GPCRs. A major challenge for the pharmaceutical industry is to associate the many novel GPCRs with disease to identify the drugs of the future. This process consists of a collection of experimental paradigms that together can be loosely labelled 'target validation'.

引用

页码：235 / 246

页数：12

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