PINK1-and Parkin-mediated mitophagy at a glance

被引:465
作者
Jin, Seok Min [1 ]
Youle, Richard J. [1 ]
机构
[1] NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA
关键词
MITOCHONDRIAL-DNA DELETIONS; SUBSTANTIA-NIGRA NEURONS; PROTEIN-DEGRADATION; PINK1/PARKIN-MEDIATED MITOPHAGY; RETICULOCYTE MATURATION; OXIDATIVE STRESS; KINASE PINK1; DISEASE; AUTOPHAGY; MUTATIONS;
D O I
10.1242/jcs.093849
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:795 / 799
页数:5
相关论文
共 60 条
  • [1] ALDIN ASN, 1994, ACTA NEUROL SCAND, V89, P347
  • [2] Mitochondrial Fusion/Fission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty
    Arduino, Daniela M.
    Raquel Esteves, A.
    Cardoso, Sandra M.
    [J]. PARKINSONS DISEASE, 2011, 2011
  • [3] High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
    Bender, A
    Krishnan, KJ
    Morris, CM
    Taylor, GA
    Reeve, AK
    Perry, RH
    Jaros, E
    Hersheson, JS
    Betts, J
    Klopstock, T
    Taylor, RW
    Turnbull, DM
    [J]. NATURE GENETICS, 2006, 38 (05) : 515 - 517
  • [4] PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
    Billia, Filio
    Hauck, Ludger
    Konecny, Filip
    Rao, Vivek
    Shen, Jie
    Mak, Tak Wah
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (23) : 9572 - 9577
  • [5] Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    Bonifati, V
    Rizzu, P
    van Baren, MJ
    Schaap, O
    Breedveld, GJ
    Krieger, E
    Dekker, MCJ
    Squitieri, F
    Ibanez, P
    Joosse, M
    van Dongen, JW
    Vanacore, N
    van Swieten, JC
    Brice, A
    Meco, G
    van Duijn, CM
    Oostra, BA
    Heutink, P
    [J]. SCIENCE, 2003, 299 (5604) : 256 - 259
  • [6] Cardoso SM, 2011, CURR PHARM DESIGN, V17, P3390
  • [7] Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
    Chan, Nickie C.
    Salazar, Anna M.
    Pham, Anh H.
    Sweredoski, Michael J.
    Kolawa, Natalie J.
    Graham, Robert L. J.
    Hess, Sonja
    Chan, David C.
    [J]. HUMAN MOLECULAR GENETICS, 2011, 20 (09) : 1726 - 1737
  • [8] Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Clark, Ira E.
    Dodson, Mark W.
    Jiang, Changan
    Cao, Joseph H.
    Huh, Jun R.
    Seol, Jae Hong
    Yoo, Soon Ji
    Hay, Bruce A.
    Guo, Ming
    [J]. NATURE, 2006, 441 (7097) : 1162 - 1166
  • [9] PINK1 cleavage at position A103 by the mitochondrial protease PARL
    Deas, Emma
    Plun-Favreau, Helene
    Gandhi, Sonia
    Desmond, Howard
    Kjaer, Svend
    Loh, Samantha H. Y.
    Renton, Alan E. M.
    Harvey, Robert J.
    Whitworth, Alexander J.
    Martins, L. Miguel
    Abramov, Andrey Y.
    Wood, Nicholas W.
    [J]. HUMAN MOLECULAR GENETICS, 2011, 20 (05) : 867 - 879
  • [10] Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
    Gegg, Matthew E.
    Cooper, J. Mark
    Chau, Kai-Yin
    Rojo, Manuel
    Schapira, Anthony H. V.
    Taanman, Jan-Willem
    [J]. HUMAN MOLECULAR GENETICS, 2010, 19 (24) : 4861 - 4870