PINK1-and Parkin-mediated mitophagy at a glance

被引:465
作者
Jin, Seok Min [1 ]
Youle, Richard J. [1 ]
机构
[1] NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA
关键词
MITOCHONDRIAL-DNA DELETIONS; SUBSTANTIA-NIGRA NEURONS; PROTEIN-DEGRADATION; PINK1/PARKIN-MEDIATED MITOPHAGY; RETICULOCYTE MATURATION; OXIDATIVE STRESS; KINASE PINK1; DISEASE; AUTOPHAGY; MUTATIONS;
D O I
10.1242/jcs.093849
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:795 / 799
页数:5
相关论文
共 60 条
  • [31] Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    Narendra, Derek
    Tanaka, Atsushi
    Suen, Der-Fen
    Youle, Richard J.
    [J]. JOURNAL OF CELL BIOLOGY, 2008, 183 (05) : 795 - 803
  • [32] p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
    Narendra, Derek P.
    Kane, Lesley A.
    Hauser, David N.
    Fearnley, Ian M.
    Youle, Richard J.
    [J]. AUTOPHAGY, 2010, 6 (08) : 1090 - 1106
  • [33] PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
    Narendra, Derek P.
    Jin, Seok Min
    Tanaka, Atsushi
    Suen, Der-Fen
    Gautier, Clement A.
    Shen, Jie
    Cookson, Mark R.
    Youle, Richard J.
    [J]. PLOS BIOLOGY, 2010, 8 (01)
  • [34] Translocation of proteins into mitochondria
    Neupert, Walter
    Herrmann, Johannes M.
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2007, 76 : 723 - 749
  • [35] p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
    Okatsu, Kei
    Saisho, Keiko
    Shimanuki, Midori
    Nakada, Kazuto
    Shitara, Hiroshi
    Sou, Yu-shin
    Kimura, Mayumi
    Sato, Shigeto
    Hattori, Nobutaka
    Komatsu, Masaaki
    Tanaka, Keiji
    Matsuda, Noriyuki
    [J]. GENES TO CELLS, 2010, 15 (08) : 887 - 900
  • [36] Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
    Paisán-Ruíz, C
    Jain, S
    Evans, EW
    Gilks, WP
    Simón, J
    van der Brug, M
    de Munain, AL
    Aparicio, S
    Gil, AM
    Khan, N
    Johnson, J
    Martinez, JR
    Nicholl, D
    Carrera, IM
    Pena, AS
    de Silva, R
    Lees, A
    Martí-Massó, JF
    Pérez-Tur, J
    Wood, NW
    Singleton, AB
    [J]. NEURON, 2004, 44 (04) : 595 - 600
  • [37] Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
    Park, Jeehye
    Lee, Sung Bae
    Lee, Sungkyu
    Kim, Yongsung
    Song, Saera
    Kim, Sunhong
    Bae, Eunkyung
    Kim, Jaeseob
    Shong, Minho
    Kim, Jin-Man
    Chung, Jongkyeong
    [J]. NATURE, 2006, 441 (7097) : 1157 - 1161
  • [38] ABNORMALITIES OF THE ELECTRON-TRANSPORT CHAIN IN IDIOPATHIC PARKINSONS-DISEASE
    PARKER, WD
    BOYSON, SJ
    PARKS, JK
    [J]. ANNALS OF NEUROLOGY, 1989, 26 (06) : 719 - 723
  • [39] The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
    Plun-Favreau, Helene
    Klupsch, Kristina
    Moisoi, Nicoleta
    Gandhi, Sonia
    Kjaer, Svend
    Frith, David
    Harvey, Kirsten
    Deas, Emma
    Harvey, Robert J.
    McDonald, Neil
    Wood, Nicholas W.
    Martins, L. Miguel
    Downward, Julian
    [J]. NATURE CELL BIOLOGY, 2007, 9 (11) : 1243 - U63
  • [40] Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    Polymeropoulos, MH
    Lavedan, C
    Leroy, E
    Ide, SE
    Dehejia, A
    Dutra, A
    Pike, B
    Root, H
    Rubenstein, J
    Boyer, R
    Stenroos, ES
    Chandrasekharappa, S
    Athanassiadou, A
    Papapetropoulos, T
    Johnson, WG
    Lazzarini, AM
    Duvoisin, RC
    DiIorio, G
    Golbe, LI
    Nussbaum, RL
    [J]. SCIENCE, 1997, 276 (5321) : 2045 - 2047