Kinetic energy of free electrons affects MALDI positive ion yield via capture cross-section

被引：17

作者：

Dashtiev, M ^{[1
]}

Frankevich, V ^{[1
]}

Zenobi, R ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF PHYSICAL CHEMISTRY A | 2006年 / 110卷 / 03期

关键词：

D O I：

10.1021/jp053343y

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A method for enhancing positive analyte ion signal in MALDI is described. The idea is based on influencing the kinetic energy of free electrons emitted from the organic/metal interface. It has been recently shown that free electrons in MALDI have energies around 1 eV. This energy is close to the maximum capture cross-section of most common MALDI matrices, leading to the efficient formation of negative matrix ions. This results in the reduction of the positive analyte ion yield. The effect can be minimized by shifting the kinetic energy of the electrons away from the maximum of the matrix capture cross-section by choosing a different substrate material.

引用

页码：926 / 930

页数：5

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