Neuroendocrine influences on cancer progression

被引:92
作者
Armaiz-Pena, Guillermo N. [1 ]
Cole, Steve W. [2 ]
Lutgendorf, Susan K. [3 ,4 ,5 ,6 ]
Sood, Anil K. [7 ,8 ,9 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Med, Div Hematol Oncol, Los Angeles, CA 90024 USA
[3] Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA
[4] Univ Iowa, Dept Urol, Iowa City, IA 52242 USA
[5] Univ Iowa, Dept Obstet & Gynecol, Iowa City, IA 52242 USA
[6] Univ Iowa, Holden Comprehens Canc Ctr, Iowa City, IA USA
[7] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA
[8] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
[9] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA
关键词
Behavioral stress; Adrenergic receptors; Metastasis; Catecholamines; Cancer; ENDOTHELIAL GROWTH-FACTOR; BETA-ADRENERGIC RECEPTORS; STRESSFUL LIFE EVENTS; KILLER-CELL ACTIVITY; EPSTEIN-BARR-VIRUS; OVARIAN-CANCER; BREAST-CANCER; TUMOR-GROWTH; PSYCHOSOCIAL FACTORS; NERVOUS-SYSTEM;
D O I
10.1016/j.bbi.2012.06.005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
During the past decade, new studies have continued to shed light on the role of neuroendocrine regulation of downstream physiological and biological pathways relevant to cancer growth and progression. More specifically, our knowledge of the effects of the sympathetic nervous system (SNS) on cancer biology has been greatly expanded by new data demonstrating how the cellular immune response, inflammatory processes, tumor-associated angiogenesis, and tumor cell invasion and survival converge to promote tumor growth. This review will summarize these studies, while synthesizing clinical, cellular and molecular research that has continued to unearth the biological events mediating the interplay between SNS-related processes and cancer progression. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:S19 / S25
页数:7
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