A new and versatile one-pot synthesis of indol-2-ones by a novel Ugi-four-component-Heck reaction

被引：69

作者：

Umkehrer, M ^{[1
]}

Kalinski, C ^{[1
]}

Kolb, E ^{[1
]}

Burdack, C ^{[1
]}

机构：

[1] Priaton GmbH, Tutzing, Germany

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 14期

关键词：

D O I：

10.1016/j.tetlet.2006.01.149

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel one-pot-synthesis of highly substituted indol-2-ones using a combination of Ugi and Fleck reaction (U-4CR-Heck) is described. The synthesized indol-2-ones represent an interesting pharmacological scaffold with Four potential points of diversity. Thus, this novel reaction-type is amenable to combinatorial high-throughput screening. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2391 / 2393

页数：3

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