Cytolethal distending toxin in Escherichia coli O157:H7:: Spectrum of conservation, structure, and endothelial toxicity

被引：47

作者：

Friedrich, Alexander W.

Lu, Shan

Bielaszewska, Martina

Prager, Rita

Bruns, Phillip

Xu, Jian-Guo

Tschape, Helmut

Karch, Helge

机构：

[1] Univ Hosp Munster, Inst Hyg, Natl Consulting Lab Hemolyt Urem Syndrome, D-48149 Munster, Germany

[2] IZKF Munster, D-48149 Munster, Germany

[3] China CDC, Natl Inst Communicable Dis Prevent & Control, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China

[4] Robert Koch Inst, Natl Reference Ctr Salmonella & Other Enter Patho, Branch Wernigerode, D-38855 Wernigerode, Germany

[5] Univ Hosp Munster, Dept Periodontol, D-48149 Munster, Germany

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2006年 / 44卷 / 05期

关键词：

D O I：

10.1128/JCM.44.5.1844-1846.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (VI's) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type.

引用

页码：1844 / 1846

页数：3

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