The protein encoded by the MFT1 gene is a targeting factor for mitochondrial precursor proteins, and not a core ribosomal protein

被引:4
作者
Beilharz, T [1 ]
Beddoe, T [1 ]
Landl, K [1 ]
Cartwright, P [1 ]
Lithgow, T [1 ]
机构
[1] LA TROBE UNIV,SCH BIOCHEM,BUNDOORA,VIC 3083,AUSTRALIA
基金
澳大利亚研究理事会;
关键词
mitochondria; ribosomal protein; protein targeting;
D O I
10.1016/S0014-5793(97)00349-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Yeast cells harboring mft1 mutations are compromised in mitochondrial protein targeting, and Mft1p has previously been identified as a ribosomal protein, However, two genes, PLC2 and YML062C, are present in the MFT1 locus, and we show that mft1 mutant cells are compromised in the function of the cytosolic protein encoded by YML062C, The ribosomal protein (YS3a) is actually encoded by the tightly linked PLC2 gene, and does not play a role in targeting proteins to the mitochondria. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码:220 / 224
页数:5
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