Apolipoprotein E4 and tau allele frequencies among Choctaw Indians

被引：29

作者：

Henderson, JN

Crook, R

Crook, J

Hardy, J ^{[1
]}

Onstead, L

Carson-Henderson, L

Mayer, P

Parker, B

Petersen, R

Williams, B

机构：

[1] Univ Oklahoma, Dept Hlth Promot Sci, Oklahoma City, OK 73190 USA

[2] Mayo Clin, Dept Neurosci, Neurogenet Lab, Jacksonville, FL 32224 USA

[3] Univ S Florida, Dept Gerontol, Tampa, FL 33613 USA

[4] Choctaw Nation Oklahoma, Oklahoma City, OK USA

[5] Mayo Clin, Dept Neurol, Rochester, MN 55509 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 324卷 / 01期

关键词：

Choctaw; genetics; tau; Alzheimer's disease; apolipoprotein E;

D O I：

10.1016/S0304-3940(02)00150-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apolipoprotein genotyping and tau haplotyping were carried out on a series of cases with dementia and controls from the Choctaw Nation of Oklahoma. Both the Apolipoprotein E4 allele frequency and the tau H2 haplotype frequency were low in the Choctaw compared with Caucasians and there was the possibility that the association between dementia and the E4 allele was weaker than in Caucasians. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：77 / 79

页数：3

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