No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

被引：34

作者：

Baker, M

Graff-Radford, D

DeVrièze, FW

Graff-Radford, N

Petersen, RC

Kokmen, E

Boeve, B

Myllykangas, L

Polvikoski, T

Sulkava, R

Verkoniemmi, A

Tienari, P

Haltia, M

Hardy, J

Hutton, M

Perez-Tur, J

机构：

[1] Mayo Clin Jacksonville, Neurogenet Labs, Jacksonville, FL 32224 USA

[2] Mayo Clin Jacksonville, Dept Neurol, Jacksonville, FL 32224 USA

[3] Mayo Clin, Dept Neurol, Minneapolis, MN USA

[4] Univ Helsinki, Dept Neurol, Helsinki, Finland

[5] Univ Helsinki, Dept Med, Helsinki, Finland

[6] Univ Helsinki, Dept Pathol, Helsinki, Finland

[7] Univ Kuopio, Dept Publ Hlth, FIN-70211 Kuopio, Finland

[8] Univ Kuopio, Dept Gen Practice, FIN-70211 Kuopio, Finland

[9] Univ Kuopio, Dept Med, FIN-70211 Kuopio, Finland

[10] Inst Biomed, Unitat Genet Mol, Valencia, Spain

来源：

NEUROSCIENCE LETTERS | 2000年 / 285卷 / 02期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

Alzheimer's disease; genetics; TAU; progressive supranuclear palsy;

D O I：

10.1016/S0304-3940(00)01057-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：147 / 149

页数：3

共 14 条

[1] Association of an extended haplotype in the tau gene with progressive supranuclear palsy [J].

Baker, M ;

Litvan, I ;

Houlden, H ;

Adamson, J ;

Dickson, D ;

Perez-Tur, J ;

Hardy, J ;

Lynch, T ;

Bigio, E ;

Hutton, M .

HUMAN MOLECULAR GENETICS, 1999, 8 (04) :711-715

[2] Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer's disease [J].

Braak, H ;

Braak, E ;

Bohl, J ;

Reintjes, R .

NEUROSCIENCE LETTERS, 1996, 210 (02) :87-90

[3] A polymorphism in the tau gene associated with risk for Alzheimer's disease [J].

Bullido, MJ ;

Aldudo, J ;

Frank, A ;

Coria, F ;

Avila, J ;

Valdivieso, F .

NEUROSCIENCE LETTERS, 2000, 278 (1-2) :49-52

[4] Genetic evidence for the involvement of tau in progressive supranuclear palsy [J].

Conrad, C ;

Andreadis, A ;

Trojanowski, JQ ;

Dickson, DW ;

Kang, D ;

Chen, XH ;

Wiederholt, W ;

Hansen, L ;

Masliah, E ;

Thal, LJ ;

Katzman, R ;

Xia, Y ;

Saitoh, T .

ANNALS OF NEUROLOGY, 1997, 41 (02) :277-281

[5] No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples [J].

Crawford, F ;

Freeman, M ;

Town, T ;

Fallin, D ;

Gold, M ;

Duara, R ;

Mullan, M .

NEUROSCIENCE LETTERS, 1999, 266 (03) :193-196

[6] SINGLE-DAY APOLIPOPROTEIN-E GENOTYPING [J].

CROOK, R ;

HARDY, J ;

DUFF, K .

JOURNAL OF NEUROSCIENCE METHODS, 1994, 53 (02) :125-127

[7] Amyloid, the presenilins and Alzheimer's disease [J].

Hardy, J .

TRENDS IN NEUROSCIENCES, 1997, 20 (04) :154-159

[8] Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 [J].

Hutton, M ;

Lendon, CL ;

Rizzu, P ;

Baker, M ;

Froelich, S ;

Houlden, H ;

Pickering-Brown, S ;

Chakraverty, S ;

Isaacs, A ;

Grover, A ;

Hackett, J ;

Adamson, J ;

Lincoln, S ;

Dickson, D ;

Davies, P ;

Petersen, RC ;

Stevens, M ;

de Graaff, E ;

Wauters, E ;

van Baren, J ;

Hillebrand, M ;

Joosse, M ;

Kwon, JM ;

Nowotny, P ;

Che, LK ;

Norton, J ;

Morris, JC ;

Reed, LA ;

Trojanowski, J ;

Basun, H ;

Lannfelt, L ;

Neystat, M ;

Fahn, S ;

Dark, F ;

Tannenberg, T ;

Dodd, PR ;

Hayward, N ;

Kwok, JBJ ;

Schofield, PR ;

Andreadis, A ;

Snowden, J ;

Craufurd, D ;

Neary, D ;

Owen, F ;

Oostra, BA ;

Hardy, J ;

Goate, A ;

van Swieten, J ;

Mann, D ;

Lynch, T .

NATURE, 1998, 393 (6686) :702-705

[9] A full genome scan for late onset Alzheimer's disease [J].

Kehoe, P ;

Wavrant-De Vrieze, F ;

Crook, R ;

Wu, WS ;

Holmans, P ;

Fenton, I ;

Spurlock, G ;

Norton, N ;

Williams, H ;

Williams, N ;

Lovestone, S ;

Perez-Tur, J ;

Hutton, M ;

Chartier-Harlin, MC ;

Shears, S ;

Roehl, K ;

Booth, J ;

Van Voorst, W ;

Ramic, D ;

Williams, J ;

Goate, A ;

Hardy, J ;

Owen, MJ .

HUMAN MOLECULAR GENETICS, 1999, 8 (02) :237-245

[10] Tau gene polymorphisms and apolipoprotein E ε4 may interact to increase risk for Alzheimer's disease [J].

Lilius, L ;

Fabre, SF ;

Basun, H ;

Forsell, C ;

Axelman, K ;

Mattila, K ;

Andreadis, A ;

Viitanen, M ;

Winblad, B ;

Fratiglioni, L ;

Lannfelt, L .

NEUROSCIENCE LETTERS, 1999, 277 (01) :29-32

← 1 2 →