Microbiota regulation of inflammatory bowel disease and colorectal cancer

被引：60

作者：

Liu, Zhanju ^{[1
]}

Cao, Anthony T. ^{[2
]}

Cong, Yingzi ^{[2
,3
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 10, Dept Gastroenterol, Shanghai 200072, Peoples R China

[2] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[3] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2013年 / 23卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Microbiota; Inflammatory bowel disease; Colorectal cancer; T cells; Innate cells; Toll-like receptor; INTESTINAL EPITHELIAL-CELLS; SEGMENTED FILAMENTOUS BACTERIA; INVASIVE ESCHERICHIA-COLI; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTOR-4; T-BET DEFICIENCY; GUT MICROBIOTA; ULCERATIVE-COLITIS; CROHNS-DISEASE; COMMENSAL MICROBIOTA;

D O I：

10.1016/j.semcancer.2013.09.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The host and microbiota have evolved mechanisms for coexistence over millions of years. Accumulating evidence indicates that a dynamic mutualism between the host and the commensal microbiota has important implications for health, and microbial colonization contributes to the maintenance of intestinal immune homeostasis. However, alterations in communication between the mucosal immune system and gut microbial communities have been implicated as the core defect that leads to chronic intestinal inflammation and cancer development. We will discuss the recent progress on how gut microbiota regulates intestinal homeostasis and the pathogenesis of inflammatory bowel disease and colorectal cancer. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：543 / 552

页数：10

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