New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology

被引：16

作者：

Kilduff, Thomas S. ^{[1
]}

Lein, Ed S. ^{[2
]}

de la Iglesia, Horacio ^{[3
]}

Sakurai, Takeshi ^{[4
]}

Fu, Ying-Hui ^{[5
]}

Shaw, Paul ^{[6
]}

机构：

[1] SRI Int, Biosci Div, Menlo Pk, CA 94025 USA

[2] Allen Inst Brain Sci, Dept Neurosci, Seattle, WA 98103 USA

[3] Univ Washington, Dept Biol, Seattle, WA 98195 USA

[4] Kanazawa Univ, Dept Mol Neurosci & Integrat Physiol, Kanazawa, Ishikawa 9208640, Japan

[5] Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA 94158 USA

[6] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA

来源：

JOURNAL OF NEUROSCIENCE | 2008年 / 28卷 / 46期

基金：

美国国家卫生研究院;

关键词：

homeostatic system; circadian system; sleep timing; sleep deprivation; hypocretin/orexin system; sleep and learning;

D O I：

10.1523/JNEUROSCI.3768-08.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Understanding the mechanisms that underlie the control of sleep and wakefulness is a major research area in neuroscience. This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field. The studies discussed below use organisms ranging from flies to humans and focus on the interaction between the sleep homeostatic and circadian systems, the consequences of mutations in genes involved in the circadian clock on sleep timing, the effects of sleep deprivation on brain gene expression, the discovery of "sleep active" neurons in the cerebral cortex, the role of the hypocretin/orexin system in the maintenance of sleep and wakefulness, and the interaction between sleep and learning.

引用

页码：11814 / 11818

页数：5

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