Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain

被引：721

作者：

Sun, LX

Hui, AM

Su, Q

Vortmeyer, A

Kotliarov, Y

Pastorino, S

Passaniti, A

Menon, J

Walling, J

Bailey, R

Rosenblum, M

Mikkelsen, T

Fine, HA ^{[1
]}

机构：

[1] NCI, Neurooncol Branch, NINDS, NIH, Bethesda, MD 20892 USA

[2] NINDS, Dept Neurosurg, NIH, Bethesda, MD 20892 USA

[3] Univ Maryland, Sch Med, Greenebaum Canc Ctr, Baltimore, MD 21201 USA

[4] NIH, Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20814 USA

[5] Henry Ford Hosp, Hermelin Brain Tumor Ctr, Dept Neurol, Detroit, MI 48202 USA

[6] Henry Ford Hosp, Hermelin Brain Tumor Ctr, Dept Neurosurg, Detroit, MI 48202 USA

来源：

CANCER CELL | 2006年 / 9卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2006.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stem cell factor (SCF) is overexpressed by neurons following brain injury as well as by glioma cells; however, its role in gliomagenesis remains unclear. Here, we demonstrate that SCF directly activates brain microvascular endothelial cells (ECs) in vitro and induces a potent angiogenic response in vivo. Primary human gliomas express SCF in a grade-dependent manner and induce normal neurons to express SCF in brain regions infiltrated by glioma cells, areas that colocalize with prominent angiogenesis. Downregulation of SCF inhibits tumor-mediated angiogenesis and glioma growth in vivo, whereas overexpression of SCF is associated with shorter survival in patients with malignant gliomas. Thus, the SCF/c-Kit pathway plays an important role in tumor- and normal host cell-induced angiogenesis within the brain.

引用

页码：287 / 300

页数：14

共 53 条

[31]

NATALI PG, 1992, CANCER RES, V52, P6139

[32] Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors [J].